Startups in the United States

The Innovative EcoSystems registry lists 1,456 startups in the United States.

Startups are young companies building new products or business models.

The largest concentrations are in Cincinnati, Ohio (69), Boulder, Colorado (57) and Richmond, Virginia (52).

The United States scores 68.5 out of 100 on the IEPA (2024 edition), ranking 21 of 117 economies.

See the United States on the IEPA ↗

1,456 startups

• CartilaGen
  Startup · Coralville · cartilagen.com
• Casentric
  Startup · Cleveland · casentric.com
• Cast21
  Startup · Chicago · cast21.com
• Catalyze
  Startup · Boulder · catalyze.energy
• Centerline Biomedical
  Startup · Cleveland · centerlinebiomedical.com
• Cerebelly
  Startup · Erie · cerebelly.com
• CereHive
  Startup · Richmond · cerehive.com
• Ceresant Solutions
  Startup · Richmond · ceresant.com
• Cerillo
  Startup · Charlottesville · cerillo.bio
• Cerus Fitness
  Startup · Frederick · cerusfitness.com
• Chimney Trail Co
  Startup · Windsor · chimneytrail.com
• ChopLocal
  Startup · Wayland · choplocal.com
• Chowbus
  Startup · Chicago · chowbus.com
• ChowCall
  Startup · Norfolk · chowcall.net
• Cime Therapeutics
  Startup · Denver · cimetherapeutics.com
• Cinnabar Optics
  Startup · Erie · cinnabaroptics.com
• Circulo
  Startup · Columbus · circulohealth.com
• Citra
  Startup · Colorado Springs · citra.space
• Clarametyx Biosciences
  Startup · Columbus · clarametyx.com
• Clayton Farms
  Startup · Ames · claytonfarms.com
• Clearly Acquired
  Startup · Windsor · clearlyacquired.com
• CLEATUS
  Startup · Arlington · cleat.ai
• Cleveland Diagnostics
  Startup · Cleveland · cleveland-diagnostics.com
• ClinicNote
  Startup · Des Moines · clinicnote.com
• Clockwork
  Startup · Charlottesville · clockwork.app
• Code One Training Solutions
  Startup · Roanoke · code1web.com
• Collage
  Startup · Denver · collage.inc
• Collamedix
  Startup · Cleveland · collamedixinc.com
• College Raptor
  Startup · Iowa City · collegeraptor.com
• Complion
  Startup · Closed · complion.com
• Conductor Solar
  Startup · Athens · conductor.solar
• Construct CRM
  Startup · Delray Beach · constructcrm.com
• CONTACT (Contact CI)
  Startup · Cincinnati · contactci.co
• Content Status
  Startup · Cleveland · contentstatus.com
• Continuum Ag
  Startup · Washington · continuum.ag
• Contraline
  Startup · Charlottesville · contraline.com
• Convelo Therapeutics
  Startup · Cleveland · convelotx.com
• ConX
  Startup · Castle Rock · conx-usa.com
• Coologics
  Startup · Broadview Heights · vlisse.com
• Cordata Healthcare Innovations
  Startup · Cincinnati · cordatahealth.com
• Corellium
  Startup · Delray Beach · corellium.com
• CoreWater Technologies
  Startup · Oberlin · corewatertech.com
• Corsha
  Startup · Vienna · corsha.com
• Coviance
  Startup · West Des Moines · coviance.com
• CrabLine Robotics
  Startup · Cleveland · crablinerobotics.com
• Credible Data
  Startup · Boulder · credibledata.com
• Crop Convergence
  Startup · cropconvergence.com
• CryoThermic Systems
  Startup · Chagrin Falls · cryothermicsystems.com
• CryptoSlam
  Startup · Overland Park · cryptoslam.io
• CTQ-Spine
  Startup · Moreland Hills · ctq-spine.com
• CXperks
  Startup · Norfolk · 757collab.org
• Cyrano Therapeutics
  Startup · Delray Beach · cyranotherapeutics.com
• CytoRecovery
  Startup · Blacksburg · cytorecovery.com
• D'Angelo Technologies
  Startup · Xenia · dangelotech.com
• Dandelion Energy
  Startup · Mount Kisco · dandelionenergy.com
• Datag
  Startup · dataginc.com
• Dazos
  Startup · Boca Raton · dazos.com
• DealVue
  Startup · Cincinnati · dealvue.io
• Deem
  Startup · Closed · Overland Park · usedeem.com
• DEFCON AI
  Startup · McLean · defconai.com
• Delectable AI
  Startup · Colorado Springs · delectableai.com
• Delivered
  Startup · Cleveland · shipdelivered.com
• Denim Social
  Startup · Des Moines · denimsocial.com
• DenScore
  Startup · Traverse City · denscore.com
• Derive
  Startup · Richmond · deriverisk.com
• Design Mill
  Startup · Dubuque · designmillinc.com
• Devorto
  Startup · Newport News · devorto.io
• Dexa
  Startup · Dayton · flydexa.com
• DifferentKind
  Startup · Buena Vista · differentkind.com
• Diraq
  Startup · Chicago · diraq.com
• Distynct
  Startup · Ames · getdistynct.com
• docket
  Startup · Cleveland · usedocket.com
• Dot Drives
  Startup · Lynchburg · dotdrives.com
• Dressit
  Startup · Coldwater · dressit.ai
• Drive My Way
  Startup · Cleveland · drivemyway.com
• Dryland Genetics
  Startup · Ames · drylandgenetics.com
• Dunami
  Startup · Overland Park · dunami.com
• DVM Systems
  Startup · Greeley · dvmsystems.com
• Dwolla
  Startup · Des Moines · dwolla.com
• Ear Micro
  Startup · Kansas City · earmicro.com
• EarthaPro
  Startup · Haymarket · earthapro.com
• EarthSense
  Startup · Champaign · earthsense.co
• Easymetering
  Startup · Boca Raton · easymetering.com
• Echogen Power Systems
  Startup · Akron · echogen.com
• Ecoshell
  Startup · Cincinnati · ecoshell.eco
• Edge Drone Services
  Startup · Martin County · edgedroneservices.com
• EdgeData
  Startup · Cedar Rapids · edgedata.net
• Edifice Analytics
  Startup · Cleveland · edificeanalytics.com
• EDTCH (Konstantly)
  Startup · Virginia Beach · konstantly.com
• EggNest.ai
  Startup · Grand Junction · eggnest.ai
• Elephant Energy
  Startup · Boulder · elephantenergy.com
• ElevatorZip
  Startup · Rocky River · elevatorzip.com
• Elias Animal Health
  Startup · Lenexa · eliasanimalhealth.com
• Elio Mortgage
  Startup · Port St. Lucie · eliomortgage.com
• Ellequate
  Startup · Cincinnati · ellequate.com
• Eloo AI
  Startup · Findlay · eloo.ai
• Embody
  Startup · Norfolk · embody-inc.com
• EMode Photonix
  Startup · Boulder · emodephotonix.com
• Enclavia (formerly IntraIntel.ai)
  Startup · Fairfax · enclavia.ai
• encoord
  Startup · Edgewater · encoord.com
• EndoEvolve
  Startup · Columbus · endoevolve.com
• Endolith
  Startup · Arvada · endolithmining.com
• Enduralock
  Startup · Lenexa · enduralock.com
• Enlace Health
  Startup · Columbus · enlacehealth.com
• enosix
  Startup · Cincinnati · enosix.com
• Epivara
  Startup · Champaign · epivara.com
• Equal Edge
  Startup · Dover · equaledgeu.com
• EqualityMD
  Startup · Richmond · equalitymd.com
• eSumry
  Startup · Norfolk · esumry.com
• Eunoia Bra
  Startup · Henrico · eunoiabra.com
• Everactive
  Startup · Charlottesville · everactive.com
• Everyday Life
  Startup · Somerville · everydaylifeinsurance.com
• Express Tec
  Startup · Junction City · expresstec.bio
• Factorem
  Startup · factorem.com
• Fallinje
  Startup · Steamboat Springs · fallinje.com
• Farm Dog
  Startup · Des Moines · atrustedear.org
• Farmers Risk
  Startup · Ames · farmersrisk.ag
• FarrPro
  Startup · Iowa City · farrpro.com
• FBB Biomed
  Startup · Coralville · fbbbio.com
• Fermi Energy
  Startup · Blacksburg · fermienergy.com

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Cities

• Startups in Cincinnati, Ohio 69
• Startups in Boulder, Colorado 57
• Startups in Richmond, Virginia 52
• Startups in Denver, Colorado 50
• Startups in Columbus, Ohio 47
• Startups in Cleveland, Ohio 42
• Startups in Ames, Iowa 40
• Startups in Tulsa, Oklahoma 33
• Startups in Chicago, Illinois 32
• Startups in Des Moines, Iowa 31
• Startups in Oklahoma City, Oklahoma 29
• Startups in Iowa City, Iowa 28
• Startups in Norman, Oklahoma 24
• Startups in Boca Raton, Florida 22
• Startups in Charlottesville, Virginia 22
• Startups in Lawrence, Kansas 19
• Startups in Overland Park, Kansas 18
• Startups in Cedar Rapids, Iowa 16
• Startups in Coralville, Iowa 16
• Startups in Dayton, Ohio 16
• Startups in Fort Collins, Colorado 16
• Startups in Wichita, Kansas 15
• Startups in Blacksburg, Virginia 14
• Startups in Alexandria, Virginia 13
• Startups in Norfolk, Virginia 12
• Startups in Roanoke, Virginia 12
• Startups in Toledo, Ohio 12
• Startups in West Palm Beach, Florida 11
• Startups in Arlington, Virginia 10
• Startups in Aurora, Colorado 10
• Startups in Colorado Springs, Colorado 10
• Startups in Golden, Colorado 9
• Startups in Hampton, Virginia 9
• Startups in Greeley, Colorado 8
• Startups in McLean, Virginia 8
• Startups in Akron, Ohio 7
• Startups in Champaign, Illinois 7
• Startups in Dublin, Ohio 7
• Startups in Erie, Colorado 7
• Startups in Longmont, Colorado 7
• Startups in Reston, Virginia 7
• Startups in West Des Moines, Iowa 7
• Startups in Cedar Falls, Iowa 6
• Startups in Fairfield, Iowa 6
• Startups in Jupiter, Florida 6
• Startups in Leawood, Kansas 6
• Startups in Lenexa, Kansas 6
• Startups in Broomfield, Colorado 5
• Startups in Chagrin Falls, Ohio 5
• Startups in Davenport, Iowa 5
• Startups in Delray Beach, Florida 5
• Startups in Hilliard, Ohio 5
• Startups in Lafayette, Colorado 5
• Startups in Olathe, Kansas 5
• Startups in Palm Beach Gardens, Florida 5
• Startups in Ankeny, Iowa 4
• Startups in Clive, Iowa 4
• Startups in Durango, Colorado 4
• Startups in Edmond, Oklahoma 4
• Startups in Englewood, Colorado 4
• Startups in Henrico, Virginia 4
• Startups in Kansas City, Kansas 4
• Startups in Littleton, Colorado 4
• Startups in Manhattan, Kansas 4
• Startups in Mason, Ohio 4
• Startups in Sioux City, Iowa 4
• Startups in Virginia Beach, Virginia 4
• Startups in Youngstown, Ohio 4
• Startups in Buena Vista, Colorado 3
• Startups in Centennial, Colorado 3
• Startups in Council Bluffs, Iowa 3
• Startups in Fairfax, Virginia 3
• Startups in Grand Junction, Colorado 3
• Startups in Greenwood Village, Colorado 3
• Startups in Herndon, Virginia 3
• Startups in Loveland, Colorado 3
• Startups in Milford, Ohio 3
• Startups in Newport News, Virginia 3
• Startups in Prairie Village, Kansas 3
• Startups in Topeka, Kansas 3
• Startups in Urbandale, Iowa 3
• Startups in Windsor, Colorado 3
• Startups in Xenia, Ohio 3